* Decide if you want to win a large amount of money once or twice, or small amounts over several games. This will play hugely into your strategy.
* If you wish to win bigger amounts, you will want to place a larger bet on a smaller number of games. For instance, if the minimum bet is $1, you may want to place several dollars on a game, that way your payout is much larger if you win. You will also have to pick the max amount of numbers, as this is the only way to get the large jackpot.
* If you wish to simply have more playing time and don't necessarily care if you win the huge jackpot, you can pick fewer numbers. Doing so makes it easier for you to hit 100% of your numbers, thus ensuring a payout. However, the amount will be small, as your payout is proportional to the number of picks you made. Also, you would bet a smaller amount on each ticket, so that you can play more games. Your bankroll will last a whole lot longer this way.
* Realize that numbers in Keno are randomly generated. Therefore, just because a number has not come up for several games, it does not mean that the number will 'hit' the next time out. Technically speaking, a single number could never come up for dozens of games in a row because of the random number generators used at most casinos may simply never pick it.
* If your online casino offers free practice games, it is advisable to take advantage of this, as it can help you get a feel for the game and ensure you do not make a mistake in picking your numbers.
* Play for fun only. This is good advice for any game of chance. If you play expecting to win, you will be sorely disappointed, as big wins in Keno are rare. Play for fun and without expectations of winning, and you will then be pleasantly surprised if you do win.
* Decide on a bankroll and stick to it. Whatever amount of money you decide on, do not spend more than that. If you do, it will likely only lead to further loses.